Professor Debbie Lucy Hay
BSc (hons), PhD
2002 PhD (Molecular Pharmacology), Imperial College London, UK.
1999 BSc (Hons) in Pharmacology, University of Sheffield, UK.
Research | Current
Research in the Hay laboratory focuses on G protein-coupled receptors (GPCRs). These proteins are the cellular targets of natural hormones and are some of the most important drug targets. The research aims to contribute to the development of medicines to treat migraine, cancer, lymphatic insufficiency, cardiovascular disease, obesity and diabetes, whilst revealing fundamental mechanisms of cell signalling. A particular focus of the lab is class B GPCRs and their interactions with accessory proteins known as “receptor activity-modifying proteins”.
Work in the lab spans a range of areas with local and international collaborators, including: pharmacology, medicinal chemistry, peptide chemistry, structural biology, molecular biology, immunohistochemistry and culture of cell lines and primary cells. Debbie also has a particular interest in receptor nomenclature in association with the International Union of Pharmacology.
Teaching | Current
Current Head of School with no teaching for 2019.
2018 Gavin and Ann Kellaway Medical Research Fellowship from the Auckland Medical Research Foundation
2018 School of Biological Sciences Researcher of the Year Award for outstanding contributions to research in 2017
2016 British Journal of Pharmacology Editor Performance Award
2016 James Cook Fellowship from the Royal Society of New Zealand (2017-2019)
2015 Tregear Award from the Australian Peptide Association for outstanding research in the field of peptide chemistry and biology and underpinning technologies.
2014 Faculty of Science Dean’s Award for Teaching Excellence
2013 Novartis Prize for published work (British Pharmacological Society)
2013 Custom Science New Zealand Society for Biochemistry and Molecular Biology Award (senior scientist award)
2009 Invitrogen Life Science Award for excellence in molecular biology in New Zealand
2008 Early Career Research Excellence Award (University of Auckland)
2007 Promising Researcher Award, Queenstown Molecular Biology Meeting, New Zealand
2005 Denis Wade Johnson & Johnson New Investigator Award (ASCEPT)
2003 Young Investigator Award, Neuropeptides 2003, Montauk, New York, USA
2001 Young Investigator Award, Fourth International Meeting on CGRP, Copenhagen, Denmark
2000 Young Investigator Award, Second International Conference on Adrenomedullin and PAMP, Miyazaki, Japan
2018- Elected Fellow of the British Pharmacological Society (FBPhS)
2018- Appointed Principal investigator of the Maurice Wilkins Centre
2012- Corresponding Member (invited) of NC-IUPHAR (one of only 28 worldwide)
The International Union of Pharmacology Committee on Receptor Nomenclature and Drug Classification (NC-IUPHAR) has the mission of issuing guidelines for classifying pharmacological targets, and addressing the main issues in pharmacology today
2010- Principal investigator of the Centre for Brain Research
2009-18 Associate investigator of the Maurice Wilkins Centre
Areas of expertise
Receptor accessory proteins (RAMPs), peptide hormones, CGRP, migraine, amylin, adrenomedullin, calcitonin, GPCRs
2015- Editorial board member of the British Journal of Pharmacology.
Selected publications and creative works (Research Outputs)
- Hendrikse, E. R., Bower, R. L., Hay, D. L., & Walker, C. S. (2019). Molecular studies of CGRP and the CGRP family of peptides in the central nervous system. Cephalalgia : an international journal of headache, 39 (3), 403-419. 10.1177/0333102418765787
Other University of Auckland co-authors: Christopher Walker, Erica Hendrikse
- Liang, Y.-L., Khoshouei, M., Deganutti, G., Glukhova, A., Koole, C., Peat, T. S., ... Miller, L. J. (2018). Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor. Nature, 561 (7724), 492-497. 10.1038/s41586-018-0535-y
- Williams, E. T., Harris, P. W. R., Jamaluddin, M. A., Loomes, K. M., Hay, D. L., & Brimble, M. A. (2018). Solid-Phase Thiol-Ene Lipidation of Peptides for the Synthesis of a Potent CGRP Receptor Antagonist. Angewandte Chemie (International ed. in English), 57 (36), 11640-11643. 10.1002/anie.201805208
Other University of Auckland co-authors: Margaret Brimble, Elyse Williams, Paul Harris, Kerry Loomes, Aqfan Jamaluddin
- Simms, J., Uddin, R., Sakmar, T. P., Gingell, J. J., Garelja, M. L., Hay, D. L., ... Poyner, D. R. (2018). Photoaffinity Cross-Linking and Unnatural Amino Acid Mutagenesis Reveal Insights into Calcitonin Gene-Related Peptide Binding to the Calcitonin Receptor-like Receptor/Receptor Activity-Modifying Protein 1 (CLR/RAMP1) Complex. Biochemistry, 57 (32), 4915-4922. 10.1021/acs.biochem.8b00502
Other University of Auckland co-authors: Margaret Brimble, Joseph Gingell, Michael Garelja, Paul Harris
- Dal Maso, E., Zhu, Y., Pham, V., Reynolds, C. A., Deganutti, G., Hick, C. A., ... Wang, M.-W. (2018). Extracellular loops 2 and 3 of the calcitonin receptor selectively modify agonist binding and efficacy. Biochemical pharmacology, 150, 214-244. 10.1016/j.bcp.2018.02.005
- Garelja, M. L., Walker, C. A., Siow, A., Yang, S. H., Harris, P. W. R., Brimble, M. A., ... Hay, D. L. (2018). Receptor Activity Modifying Proteins Have Limited Effects on the Class B G Protein-Coupled Receptor Calcitonin Receptor-Like Receptor Stalk. Biochemistry, 57 (8), 1410-1422. 10.1021/acs.biochem.7b01180
Other University of Auckland co-authors: Margaret Brimble, Sung Hyun Yang, Joseph Gingell, Michael Garelja, Paul Harris, Christopher Walker
- Hay, D. L., Garelja, M. L., Poyner, D. R., & Walker, C. S. (2018). Update on the pharmacology of calcitonin/CGRP family of peptides: IUPHAR Review 25. British journal of pharmacology, 175 (1), 3-17. 10.1111/bph.14075
Other University of Auckland co-authors: Michael Garelja, Christopher Walker
- Walker, C. S., Raddant, A. C., Woolley, M. J., Russo, A. F., & Hay, D. L. (2018). CGRP receptor antagonist activity of olcegepant depends on the signalling pathway measured. Cephalalgia, 38 (3), 437-451. 10.1177/0333102417691762
Other University of Auckland co-authors: Christopher Walker